...Retinoids Help Normalize KeratinizationAlthough the mechanism by which topical and systemic retinoids help restore acne follicles to a healthy state is unknown, it has been well demonstrated that they normalize keratinization within the infundibular region of the follicle, so that shed follicular cells slough to the surface of the skin rather than clump together and obstruct the pores.After exposure to retinoids, follicular cells actually turn over more rapidly than they would in a pre-acne state.Retinoic acid has a high affinity for the gamma retinoid receptors, which are believed to be integral to the pathogenesis of acne.In addition to their ability to reverse abnormal keratinization within the follicle, the topical retinoids - especially adapalene (Differin®), a naphthoic acid derivative - may have anti-inflammatory properties and thus may address two factors involved in the development of acne....»
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«...Although the cause of acne is not fully understood, it is believed to occur when the sebaceous glands increase their production of the oily sebum, which appears to be promoted by hormonal activity. Sebum mixes with dead skin cells to block the pores in the skin and this mass become infected with bacteria. Your body's immune system reacts to cause inflammation and the formation of pus, the detritus of white blood cells that have been active in destroying the bacteria....»
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